New generation of broad-spectrum antibiotics tigecycline officially listed in China

A few days ago, Pfizer announced that its new generation of broad-spectrum antibiotics, "Taige" (Tegacycline), will be officially listed in China.

In recent years, the challenges faced by clinical anti-infective treatments are increasing. The nosocomial infection caused by multiple drug resistant bacteria (MDRO) has seriously affected medical safety and patient safety, and has become an important clinical challenge. Multi-drug resistant bacteria mainly refer to bacteria that are resistant to three or more types of antimicrobial agents that are clinically used at the same time. These bacteria are often responsible for the failure of clinical anti-infective treatments. What is more noteworthy is that the incidence of multiple drug-resistant bacteria is increasing year by year.

The famous domestic anti-infection expert and Director of Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai Hu Hujie said that the main types of infections caused by multiple drug-resistant bacteria include urinary tract infections, surgical site infections, hospital-acquired pneumonia, etc. Treatment is difficult and so on. The multi-drug resistant nosocomial infection has become an important reason for prolonging hospitalization time, increasing medical expenses and leading to death of patients. If treatment is not timely, it may even cause death.

Pfizer's anti-drug-resistant intravenous antibiotic drug Taige can overcome common efflux pump and ribosome protection and other bacterial resistance mechanisms, and is not easy to produce drug resistance, the scope of application at the same time coverage of drug-resistant bacteria, resistant Drug-positive bacteria, anaerobic bacteria, and atypical pathogens can treat a variety of existing antibiotic-resistant drug-resistant bacterial infections, including superbugs. It is worth noting that some potent antibacterial drugs have greater side effects of liver and kidney while treating the disease, while Thai pavilion is excreted in dual channels and has good liver and kidney safety.