Jak/Stat signal path diagram

The JAK-STAT signaling pathway is a signal transduction pathway stimulated by cytokines discovered in recent years, and is involved in many important biological processes such as cell proliferation, differentiation, apoptosis and immune regulation. Compared with other signaling pathways, this signaling pathway is relatively simple to transfer. It consists of three components, namely tyrosine kinase-related receptor, tyrosine kinase JAK and transcription factor STAT.

The signaling process is as follows: Binding of cytokines to the corresponding receptor causes dimerization of the receptor molecule, which allows the JAK kinases coupled to the receptor to be close to each other and activated by interactive tyrosine phosphorylation. After JAK activation, the tyrosine residues on the catalytic receptor are phosphorylated, and then these phosphorylated tyrosine sites form a "docking site" with the surrounding amino acid sequence, and contain the SH2 domain. The STAT protein was recruited to this "parking site." Finally, the kinase JAK catalyzes the phosphorylation of the STAT protein bound to the receptor, and the activated STAT protein enters the nucleus as a dimer to bind to the target gene and regulate gene transcription (Fig. 5). It is worth mentioning that a JAK kinase can be involved in the signal transduction of many cytokines. A cytokine signaling pathway can also activate multiple JAK kinases, but cytokines have certain choices for activated STAT molecules. Sex. For example, IL-4 activates STAT6, while IL-12 specifically activates STAT4.

The signal molecules involved in this signal transduction mainly include:
IL-6, gp130, SHP1, SHP2, SOCS, SOCS3, GRB2, Shc, Ras, CIS, Jak, Stat, Stat3, Raf, MEK, Erk, PI3K, Akt, mTOR, Mcl-1, p120, ras-GAP, EGF, EGFR, Src, PIAS, SUMO, TF, N-PTP, CIS, SOCS, Mcl-1, APPs, TIMP-1, Pim-1, c-Myc, cytokines, TFs and the like.

Click on the signal molecule in the figure to view detailed pathway maps and products (inhibitors, antibodies, phosphorylated antibodies, assay kits, recombinant proteins, etc.):