Release date: 2016-11-04
The medical profession has been looking for a "universal" drug or method that can effectively kill tumor cells. The so-called universal means that the drug or therapy can be used to deal with almost all types of cancer. In the contemporary, it is beneficial to the future. However, human beings who have been stifling cancer for so long and are exhausted are really expected to see this day?
Now, this ideal goal seems to be just around the corner. According to a recent report by Nature, a group of international researchers recently developed a new compound that effectively inhibits the growth of many types of cancer models in the laboratory – up to four points for all known cancer types. one. This discovery may indicate that human anti-cancer has already turned a corner.
Can cancer be eliminated?
Cancer cells are as old as the earliest creatures on Earth, and they probably have never been completely eliminated.
Researchers at the University of Kiel in Germany published a study in the 2014 Nature Newsletter that cancer cells have deeper roots in evolution, and any important cells in the human body are likely to become cancerous. Hundreds of millions of years ago, cancer cells were found in coral-like miniature otters, suggesting that cancer is an inherent part of human evolution. Scientists believe that the war between humans and cancer will not win.
This conclusion brings not only pain but also despair. Is it difficult for people to cure and recover in the future if they suffer from cancer? Even if the scientific discovery is repeated and the technical means are extended, can people still do nothing about the fate of the disease?
S63845, a small molecule with multiple arrows
The emergence of a small molecule may be expected to reverse this situation.
Servier, a French-based international pharmaceutical group, and other institutions have developed a new compound that blocks a key protein that is as much as a quarter of a cancer cell. Continuous growth is essential.
This compound, designated S63845, is capable of targeting the BCL2 family protein MCL1. The protein is critical for cancer cells – a pro-survival protein that allows cancer cells to escape the process of programmed cell death. Therefore, many types of cancer rely on MCL1, and "seeking" is less than MCL1, and cancer cells will die.
According to the Australian Science and Technology News Network, the team from the Walter and Eliza-Hall Institutes in Australia has conducted extensive research in a variety of cancer models. Their study of hematological tumors showed that among the 25 multiple myeloma lines, the new compounds could kill and inhibit 23 of them; 8 of the 11 lymphoma and chronic myeloid leukemia strains were inhibited. There are also 25 patient-derived acute myeloid leukemia patient tumor cells, 7 c-myc Brucella lymphoma strains and 8 acute myeloid leukemia strains, all of which show a killing effect.
In addition, in the test for solid tumors, S63845 also performed well as long as it was used in combination with the corresponding special effects drugs.
This means that when we talk about "universal" anticancer drugs, it is no longer an idiotic dream.
New therapy, anti-cancer road dawn
In the past, radiotherapy and chemotherapy were effective ways to fight cancer cells, which could reduce cancer patients' mortality. However, these techniques often "connected" healthy cells, causing side effects such as extreme weakness. S63845 can not only cut off the life support system of cancer, but also tolerate normal cells at a certain dose, showing good development prospects.
Although the protein MCL1 targeted by S63845 plays a key role in the survival of malignant tumor cells, it is also essential for basic human functions such as hematopoiesis. Therefore, the activity of the protein cannot be completely suppressed, otherwise the human body will face death. Any form of containment must grasp this narrow treatment window, and S63845 can work within this treatment window - studies on experimental mice have shown that it does not impair hematopoiesis.
The research team said that this allowed the protein MCL1 to enter the eyes of scientists. Small molecules targeting this protein have been challenging in clinical testing for a long time, but the emergence of S63845 provides for the first time conclusive evidence that inhibition of MCL1 protein is effective in many types of cancer. More importantly, researchers can now use it to treat blood-type cancers such as acute myeloid leukemia, lymphoma, and multiple myeloma, as well as solid cancers such as melanoma, lung cancer, and breast cancer.
It will greatly help people develop new ways to kill cancer cells. This may mean that the long-awaited dawn of humanity has emerged on the difficult and long road to conquer cancer.
Source: Technology Daily
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