Although decades of genetic studies have revealed a lot of information about the cells that make up creatures. Due to the technical limitations of human and other mammalian cells, sophisticated genetic experiments are usually only possible with 'model' organisms such as yeast, fruit flies, and nematode worms. The basic discoveries in these organisms may apply to human cells in the future, but even then, the process is laborious. Researchers at Cold Spring Harbor Laboratory (CSHL) are working to change the above situation. In a study published in the February 5th, 2002 issue of the National Academy of Science, CSHL scientist Gregory Hannon and colleagues presented an article on the direct execution of mammalian cells. New analysis of genetic analysis. This technology has the potential to greatly simplify the discovery of genes and the manipulation of genes for many biomedical applications. Steven Elledge, who is familiar with the study at Baylor College of Medicine, claimed that the technology can save months of research per gene. Hannon and colleagues have developed a simple strategy that allows them to turn off any gene (or combination of genes) in a locked or random target in mouse cells. With this ability to turn off (or indirectly turn on) genes, researchers can accomplish several things. By finding out what happens to the cells when the genes are turned off, they can extrapolate the function of specific genes. In addition, by turning off the gene arbitrarily, researchers can select cells that exhibit new properties that are striking, such as improved response to cancer treatments. The latter's unprejudiced approach is a very attractive method for identifying new cancer treatments or treating other diseases as potential targets. The new study, which appeared on the online edition of the National Academy of Sciences in the United States on January 29, 2002, was produced by the National Institute of Health and the Genetica Biotech Company in Cambridge, Massachusetts. Sponsored. Dr. Hannon, co-founder of Genetica, is using the results of this research as a basis to explore ways to selectively eliminate cancer cells. Using a strategy related to the above-mentioned research and development by the Cold Spring Harbor Laboratory team, Thomas Tuschl, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany, in 2001 In a study published in the journal Nature in May of last year, similar results were obtained. However, the strategy of the Cold Spring Harbor Laboratory to shut down mammalian cell genes apparently resulted in a more stable and long-lasting observation than earlier studies. effect. Typical geneticists engaged in research with yeasts, fruit flies, and worms still have many things to contribute to the analysis of complex genetic networks that control organisms. However, this new technology can inspire researchers working with humans and other mammalian cells to experiment with genetic methods that they may have dreamed of only a few years ago.
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