A traditional Chinese medicine ingredient is effective for a specific type of leukemia
October 13, 2016 Source: Science Network
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Acute myeloid leukemia is a common cancer in the adult blood system, and nearly 30% of patients with acute myeloid leukemia carry FLT3-ITD gene mutations.
Liang Ruhong, deputy dean of the Li Ka Shing Faculty of Medicine at the University of Hong Kong, China, told Xinhua that the standard chemotherapy method and drug sorafenib are not ideal for patients with acute myeloid leukemia carrying this mutation. In order to find a better treatment, they used the patient's leukemia cells for in vitro drug screening and found that homoharringtonine significantly inhibited it.
According to Liang Ruhong, homoharringtonine is a bio-ester base extracted from the genus Cephalotaxus. In China, homoharringtonine is commonly used in the treatment of acute myeloid leukemia, but it is not specific to the type of leukemia, so the effect is not significant.
Liang Ruhong et al recruited 24 patients with acute myeloid leukemia who had relapsed or refractory FLT3-ITD gene mutations to conduct clinical trials using a combination of homoharringtonine and sorafenib. The results were obtained in 20 patients. Leukemia cells were cleared and the overall survival was significantly prolonged.
Liang Ruhong said that homoharringtonine can inhibit the protein synthesis of cells, making cancer cells unable to produce important proteins, leading to apoptosis of cancer cells. "Compared to current methods, the side effects of combination therapy are small and can be applied to frail or elderly patients," said Liang Ruhong, who provided an effective treatment strategy for FLT3-ITD acute myeloid leukemia.
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