Release date: 2018-05-31
A new finding from the University of Virginia School of Medicine suggests that the effects of other aging such as fatty liver disease may be due to wrinkling of the nucleus, which appears to prevent the normal functioning of the gene.
Although the "wrinkle essence" for the nucleus has not yet been developed, there is an attractive way to use the virus to smooth the surface of the nuclear membrane, thereby restoring the function of the cells and making them shine like young cells.
Oscillating membrane
The team of Dr. Irina M. Bochkis of the Department of Pharmacology believes that the positioning of our DNA in the nucleus is very important. The gene that was shut down was pushed onto the nuclear membrane, and as the age grew, the nuclear membrane became crumpled, and such conditions prevented the proper closure of the gene.
"Every of our cells have the same DNA, but each cell is different," Bochkis explained. “How do cells work? For example, genes that run in the liver must be turned off in the brain, and vice versa, and if they are not properly turned off, the body will go wrong.â€
When they studied the fatty liver disease model, they found that our liver was full of fat due to wrinkles in the aging of the nuclear membrane. "When the nuclear membrane is not working properly, it releases the DNA that should have been turned off, and then your small liver cells become a small fat cell."
Liver fat accumulation can cause serious health problems, increase the risk of type 2 diabetes and cardiovascular disease, and may even lead to death. "Your liver looks like a piece of Swiss cheese at the end," Bochkis said.
Membrane folds occur due to the lack of “laminâ€, a form of cellular protein that is stretched to keep the film smooth, just like “Retinol†helps facial leveling The same folds.
Bochkis has an idea: we can carry these proteins with viruses. Scientists have transformed the virus into a useful medical tool, and it is especially easy to transport the modified virus to the liver because the liver is a detoxifying organ. "If it works, you will have normal, healthy cells that will properly express the expressed gene and ban what should not exist."
Bochkis suspects that wrinkles in the nuclear membrane can also cause adverse effects on aging in other parts of the body. “Every time I discuss this with my colleagues, they will say, 'Well, do you think this is a universal mechanism?'†she said. "In my opinion, it is a universal mechanism."
Original title
Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver
Source: Biopass
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