According to data from the US Department of Health and Human Services, an average of 79 people in the United States can wait for their own organs, but another 22 people die from waiting. Waiting for organ transplantation is a long way. Now, researchers' new breakthroughs in trans-species organ transplantation may reduce the number of patients who have died due to waiting. In the future, they can be successfully implanted into the human body with pig hearts.
Organ demanders are always more than donors, and in order to solve this problem, scientists are also trying to replace the organs of other species, such as the lungs, kidneys, or heart of pigs, but ultimately Strong rejection and give up. The research team from the National Institutes of Health recently published in the journal Nature Communications. They successfully transplanted the genetically modified pig heart to the body for 945 days, and wrote a new page in the history of trans-species organ transplantation. .
The research team said that they had done three genetic modifications to the pig heart to make it more tolerant in the immune response, and at the same time let the cockroach take the anti-rejection drug and implant it in the sputum. But this pig heart did not replace the original heart, and the researcher linked it to the two large blood vessels of the abdomen to make it beat like a normal heart in the abdomen. The results were also quite unexpected. Of the 5 cockroaches that received the experiment, the pigs survived an average of 298 days, with the longest surviving being 945 days, which is equivalent to two and a half years.
This record not only breaks the previous record, but scientists are also quite excited about the arrival of a successful cross-species organ transplant in the future. Dr. Muhammad Mohiuddin of the National Heart, Lung and Blood Institute, and co-author of the study, said: "This study is quite important because it allows us to use these organs in humans. The day went one step further."
Although this result is quite forward-looking, there are quite a few factors that scientists are not currently able to grasp. For example, some scholars worry that if one day, cross-species organs are applied to humans, is it possible to bring the virus from animals to the human body, or to find the best anti-rejection drugs and genes for humans? The match between the modifiers. But for these questions, New York University bioethicist Arthur Caplan believes that scientists will have new genetic modification techniques that will allow them to succeed in the end.
The research team has succeeded in letting the pig heart survive for two and a half years. Then they will try to remove the original heart and let the pig heart replace it. In this case, How long does it take to survive? Although this experiment has not had many successful cases in the past, research scholars still have considerable confidence in the results report. Dr. Mohiuddin also said that if successful, the future will be able to obtain the organs that humans need without limit.
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