Aydogan Ozcan Research Group at Howard Hughes School of Medicine at the University of California, Los Angeles has recently developed a new technology that allows smartphones to be used as DNA scanning fluorescence microscopes.
In a recent interview with Bioscience Technology, Ozcan introduced this new technology. This is an optical accessory for a smartphone, a small 3D print cartridge that includes lenses, filters, brackets, and laser diodes that can be used to measure DNA size and DNA imaging 50,000 times thinner than human hair. After the target DNA is isolated, it is first fluorescently labeled. The Windows application on the smartphone scans the DNA molecules and transmits the information to a remote server located in the research group's lab to measure the size of the DNA molecule. The entire data processing process can be completed in 10 seconds.
Traditional microscopes are bulky, expensive, and inconvenient to transport. This new technology not only saves money, but also enables telemedicine and mobile medicine , and the use of a network-connected microscope to accumulate data from time and space to see and understand disease trends and spread from a new perspective.
Smartphone microscopes have a wide range of practical uses, such as the diagnosis of laboratory malaria and tuberculosis, as well as blood diseases or contamination detection in food. In addition, it allows some infirmary clinics to have advanced testing equipment and narrow the gap between medical conditions in urban and remote areas. Another use in the United States is for patients with chronic conditions and the elderly, such as diabetics and patients with chronic kidney disease, who can test at home every few hours. These data allow doctors to better track patients.
However, this new microscope can now accurately measure DNA molecules larger than 10,000 base pairs, and its accuracy will be greatly reduced for DNA molecules of less than 5000 base pairs. Researchers say that this problem can be solved by using a lens with a larger aperture. Next, the Ozcan team will test the use of the microscope in malaria-related drug resistance testing, as well as other new instruments developed by the test team and compare it to existing FDA-approved laboratory equipment.
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