On December 27th, Shanghai Haoyu Medical Technology Co., Ltd. (hereinafter referred to as “Shenyu Medical â€) announced today that it has completed 100 million rounds of round-the-clock financing, including Yingke Capital Leading Investment, Hetang Venture Capital, and Ruyin Medical Fund. The Zeze Fund continued to follow suit. After the completion of the financing, Pacific Century Capital won a board seat.
Haoyu Medical is a company that develops, manufactures and sells heart valve interventional medical devices. It was established in December 2016. The company's core product is the mitral valve intervention valve ValveClamp for minimally invasive interventional treatment of mitral regurgitation. In January 2018, Haoyu Medical received capital increase from investors such as Guotou Chuanghe. Other investors that have been introduced include Tiger, Power Capital, Anlong Fund, and Zhangze Investment.
With the advent and acceleration of China's aging, the incidence of cardiovascular disease is more frequent, and there are a large number of patients with mitral regurgitation. At present, the only effective method for the treatment of moderate to severe mitral regurgitation is surgical thoracotomy, but thoracotomy has the disadvantages of large trauma, high risk, pain, slow recovery, etc. A large number of patients are not treated because of the high risk of surgery. . ValveClamp is implanted without a conventional surgical procedure and is implanted through a peripheral artery (or apex) for patients with mitral regurgitation who are unable to undergo surgery and who are unwilling to have a surgically younger procedure.
Currently, the only approved mitral regurgitation minimally invasive treatment device in the world is Abbott’s MitraClip. According to Abbott’s public information and large-scale clinical research, the safety and effectiveness of MitraClip products are confirmed. As indications continue to increase, Mitraclip is expected to be a strong growth point for Abbott.
The ValveClamp technology is the same as the MitraClip and is based on the surgical "edge-to-edge stitching" technique. But compared to MitraClip, ValveClamp, the delivery system model is smaller (14F, MitraClip is 24F), and the average catheter operation time is 36 minutes, significantly shorter than MitraClip (157 minutes), Mitralign (124 minutes), Cardioband (186 minutes) and Neochord (120 minutes) and several of the most mature mitral valve repair devices in the world.
On the domestic front, there are no marketed mitral regurgitation minimally invasive interventional devices. In July of this year, ValveClamp successfully implemented the world's first clinical operation of apical mitral valve clamping technique at Shanghai Zhongshan Hospital and completed the last exploratory clinical trial before the end of the year. According to Hanyu Medical, multi-center, large-sample clinical trials will begin next year. If successful, ValveClamp is expected to become the first approved mitral valvular interventional device in China.
At present, due to the high technical threshold, the need for capital intensive, and the difficulty of research and development, mitral regurgitation interventional devices are regarded as one of the most popular directions for medical device research and development in the world. Hanyu Medical said that with the completion of the company's current round of financing, Sunny Medical will accelerate the launch of ValveClamp products and strengthen the research and development of new products.
According to the official website information, ValveClamp has completely domestic patents and has applied for international PCT patents. It has completed 12 exploratory clinical trials with a success rate of 100% and no serious complications. It is expected to be listed in 2020.
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