Excessive intake of fructose Pathogenic pregnant women eat fructose miscarriage fetus
Excessive intake of fructose can lead to diabetes and obesity, but for pregnant women it can also lead to placental and fetal defects, a conclusion from a new study in Nature's scientific report "Scientific Reports."
However, the study also showed that drugs currently used to treat gout and kidney stones may offset this effect.
Fructose is a sugar found in fruits, honey, and some vegetables. Food manufacturers often use it with glucose to produce high fructose corn syrup (HFCS) and add it to foods and beverages.
According to Dr. Kelle H. Moley, Ph.D., of the University of Washington School of Medicine and colleagues, there has been an increase in the intake of sugar and high fructose cereal syrups in recent years. "Since the 1970s, our actual intake of fructose far exceeds the standard value. It is increasingly important to understand the effects of fructose on human health." Previous studies have shown that high-fructose diet may increase diabetes and obesity. The risk, but the impact of high-fructose diets on maternal and fetal health, is rarely studied.
High-fructose diet results in a smaller fetus and a larger placenta
To better understand the effects of high-glucose diets on pregnant women and fetuses, the researchers gave rats high-glucose diets and standard diets during pregnancy and assessed the effect of each diet on maternal and fetal.
The researchers explained that compared with other forms of sugar, fructose decomposes differently in the body, fructose is decomposed by hepatocytes, converts sugars into triglycerides, at the same time the level of uric acid increases, and too much uric acid causes Many health problems include obesity and type 2 diabetes. In the study, the researchers found that during pregnancy, high triglyceride diets had higher triglyceride and uric acid levels in mice than the standard diet.
In addition, the researchers found that rats fed a high-glucose diet had a smaller placenta and a larger placenta than mice fed a standard feed diet. In addition high levels of uric acid and triglycerides increase the risk of maternal complications, such as pre-eclampsia and gestational diabetes.
Allopurinol can reverse the effect of high-sugar diet on maternal and fetal
The next step for researchers is to determine whether fructose has similar effects on humans. They analyzed the intake of fructose in 18 pregnant women who had undergone a caesarean section and found that the maternal high-glucose diet during pregnancy had a similar effect—an increase in uric acid levels. The researchers said that "the excess fructose may have the same negative impact on humans as mice." The results of the study showed that women should reduce fructose intake during pregnancy to avoid this negative effect.
The researchers also found that when mice given high-fructose diets took allopurinol drugs for treatment of kidney stones and gout, the effects of high fructose on the mother and fetus can be reversed because the drug reduces the placental uric acid content .
Dr. Moley pointed out that taking allopurinol in the middle and late pregnancy is generally considered safe. In addition, she also emphasized that during pregnancy, she should eat more natural foods and reduce the intake of processed foods.
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