Diabetes is no longer suffering from flesh and blood
July 17, 2018 Source: People's Network - Life Times
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];One or two injections of insulin a day make many diabetics suffer, and some patients are unable to adhere to medication even because of fear of pain. A new study from Harvard University in the United States has brought good news: an insulin oral tablet developed by scientists is expected to end insulin injection.
Dr. Samuel Mitragotri, a professor of bioengineering at Harvard University, is the developer of the oral insulin tablet. They placed the insulin in an ionic liquid consisting of choline and geranic acid and placed it in a capsule with an acid-resistant enteric coating. The capsule dissolves when it reaches the alkaline environment of the small intestine, and the liquid carried therein is released. Choline and geranic acid preparations help to penetrate the two major barriers - the tight junction of the intestinal mucus and the intestinal wall, which opens the door to macromolecular drug insulin. The experimental results show that oral insulin is very similar to conventional insulin injection. It is closer to the way in which the healthy population produces and delivers insulin to the liver, which not only overcomes the protein damage in the acidic environment of the stomach and the poor absorption in the intestine, but also avoids the adverse effects caused by long-term injection. The tablet is biocompatible, simple to manufacture, and does not degrade at room temperature for two months.
Dr. Mitragotri said that most people with diabetes can maintain blood sugar levels by routine subcutaneous injection or insulin injection through an insulin pump. In contrast, oral insulin delivery is convenient, which can reduce the risks and side effects of self-injection and improve their quality of life. (Fang Wenge)
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