The first bioengineered cornea was approved, and China's regenerative medicine made a major breakthrough
March 16, 2016 Source: Bio-Exploration
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Zou Liuhe, professor of ophthalmology at Beijing Tongren Hospital, pointed out that Ai Xinyi is a major scientific achievement and an important step in the field of regenerative medicine in China.
The acellular corneal stroma is treated by a special process to remove the cells, proteins, polysaccharides and other antigens in the cornea, retaining the natural corneal matrix collagen structure, which can be rapidly integrated with the surrounding tissues and migrate with the cells. After entering the reconstruction, the transplanted cornea gradually became transparent, and the patient's vision gradually recovered.
The clinical trial results of acellular corneal stroma showed that the total effective rate reached 94.5%, and the effect was close to human donation of the cornea.
According to Professor Zhang Mingchang, director of the Department of Ophthalmology, Wuhan Union Hospital, 47 patients from Wuhan Union Hospital participated in the world's first bioengineered corneal clinical trial, and all achieved satisfactory results after clinical treatment. Among them: Patient No. 1 has fungal keratitis, and 2/3 of the left eye is covered with gray-white ulcer lesions, which is almost blind and faces the risk of removing the eyeball. In this case, she participated in the bioengineered corneal transplantation test. At the end of September 2013, Ms. Zhou returned to the hospital for review. The visual acuity of the bioengineered cornea was restored to 0.4, and the normal eye had a visual acuity of 0.5. There was no difference between the eyes.
After the bioengineered corneal clinical trial, some postoperative follow-up results showed that the bioengineered cornea was transparent and formed a structure similar to the normal cornea, which was safe and effective.
Zou Liuhe, professor of ophthalmology at Beijing Tongren Hospital, believes that the most important feature of bioengineered cornea is its good fusion. The acellular corneal stroma is naturally integrated with the human eye. At present, some artificial corneal products in foreign countries mainly use silica gel as the material, and the patient's rejection reaction is obvious. Mr. Cui Zhanfeng, an academician of the Royal Academy of Engineering and a tenured professor of chemical engineering at Oxford University, believes that with the industrialization of bioengineered corneas, not only millions of patients in China are expected to see the light, but also in Southeast Asia and other countries that are greatly influenced by Buddhist thought. market. Especially with the recovery of the patient's vision, the corneal blind patients will be transformed into social creators by the burden of society.
Another tissue-engineered skin "Anshen Skin" is the only tissue-engineered skin with living cells in China, and is the only tissue-engineered skin product listed in China. Anal is similar to normal human skin and contains active epidermal and dermal layers. The application of Anshen Skin to burn patients can improve the healing environment of wounds, and has the advantages of speeding up healing, quickly reducing pain, protecting wounds in time, avoiding secondary trauma, reducing pigmentation and reducing scar formation.
After the explosion of the "705" bus in Hangzhou and the explosion of the "802" Zhongrong Metal Products Factory in Kunshan, the Chinese Regenerative Medicine Group quickly contacted the hospital for the wounded and made a donation. In patients with generalized III° burns, after 3 weeks of use, the wounded had a new skin formation at the body surface; another deep II° burned wounded the body after 2 weeks, and the body surface covered the wound. It heals well and has epithelial tissue formation, showing excellent clinical results.
Regenerative Medicine: A Revolution in a New Field
According to Dr. Zhang Aibing, director of the Industrial Center of China Regenerative Medicine Group, tissue engineering and regenerative medicine are using the principles of modern life sciences and engineering to develop new disciplines for the transplantation of human tissues and organs in vitro. The core of this is to establish three-dimensionality of cells and biological materials. A spatial complex, a living tissue with vitality, that reconstructs the morphology, structure, and function of a diseased tissue and achieves permanent replacement. The basic principle and method are that the normal tissue cells expanded in vitro are adsorbed on a biomaterial with good biocompatibility and absorption by the body to form a complex, and the cells are gradually degraded and absorbed by the organism. In the process of forming a new tissue that is consistent with the corresponding organs and tissues in terms of morphology and function, thereby achieving the purpose of repairing wounds and reconstructing functions.
Compared with traditional autologous or allogeneic tissues and organ transplantation, tissue engineering overcomes the problems of wound healing and insufficient donor sources, and fundamentally solves the problems of tissue and organ defect repair and functional reconstruction. Its products can be used for Improving, repairing, regenerating or replacing many tissues and organs of the human body indicates that medicine will move out of the scope of organ transplantation and step into the most challenging frontier of life sciences in the manufacture of tissues and organs. Gilbert, an American biologist and Nobel laureate, predicted: "Without 50 years, humans will be able to breed all the organs of the human body."
Tissue engineering and regenerative medicine not only provide a new treatment for relieving the suffering of patients, but also mark the arrival of the "bio-technical human era", a "new era of regenerative medicine", and a far-reaching medical revolution. Improving the quality of life and extending life expectancy has become a reality.
China Regenerative Medicine Group is a listed company on the Growth Enterprise Market of the Hong Kong Stock Exchange. It is the first high-tech enterprise specialized in R&D, production and sales of tissue engineering and regenerative medicine products in China. It has now become a leader in tissue engineering and regenerative medicine in China. enterprise. At present, China Regenerative Medicine Group has more than 30 independent intellectual property rights, and has undertaken many major scientific research projects such as “863†and “973†programs, covering skin, ocular surface, bone repair, cartilage repair, soft tissue repair and beauty. More than ten quality products in the field.
Shao Zhengkang, President of China Regenerative Medicine Group, looks forward to the four major directions for the future development of regenerative medicine in China, namely: research and development of tissue engineering products led by bioengineered cornea and tissue engineering skin; research and development and clinical application of cells and stem cells; cosmetics and anti-aging products Research and development; research and development, production and sales of high-end medical device products. China Vision Medical Group's "Vision 2020" is: By 2020, China Regenerative Medicine International Co., Ltd. will develop into a world-leading, China's first world-class regenerative medicine group, rising as a high-tech national enterprise in the forest of multinational companies. .
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