Anticonvulsant Drugs Pregabalin CAS 148553-50-8
LYRICA (pregabalin) Capsules are administered orally and are supplied as imprinted hard-shell capsules containing 25, 50, 75, 100, 150, 200, 225, and 300 mg of pregabalin, along with lactose monohydrate, cornstarch, and talc as inactive ingredients. The capsule shells contain gelatin and titanium dioxide. In addition, the orange capsule shells contain red iron oxide and the white capsule shells contain sodium lauryl sulfate and colloidal silicon dioxide. Colloidal silicon dioxide is a manufacturing aid that may or may not be present in the capsule shells. The imprinting ink contains shellac, black iron oxide, propylene glycol, and potassium hydroxide.
Pregabalin details
CAS: 148553-50-8
MF: C8H17NO2
MW: 159.23
Assay: 99%
Appearance: White Crystal Powder
Specification: CP
Package: 25kg/drum
Use:Â New antiepileptic drugs. Used in the treatment of peripheral neuropathy, or partial seizures adjuvant treatment.
Description:
Pregabalin belongs to a group of medicines known as anti-epileptic medicines, although it is prescribed for the treatment of several different conditions. You may have been prescribed it for the treatment of partial seizures, which is a type of epilepsy. A seizure is a short episode of symptoms which is caused by a burst of abnormal electrical activity in the brain. With a partial seizure, the burst of electrical activity stays in one part of the brain. Therefore, you tend to have localised or 'focal' symptoms. Pregabalin is also prescribed to treat certain types of long-lasting pain caused by damage to nerves. This type of pain, called neuropathic pain, can be caused by a number of different conditions, including diabetes (where it is called diabetic neuropathy) and shingles(where it is called postherpetic neuralgia).
COA:
ITEMS |
STANDARDS |
RESULTS |
Appearance |
A white to off white powder |
White powder |
    Identification |
A. Meets the requirement |
Complies |
B. IR: similar to Reference Substance |
Complies |
|
Loss on drying |
≤0.5% |
0.21% |
Specific Rotation |
+10.0°~+13.0° |
+10.8° |
Related Substances |
Any single impurity ≤0.1% Total impurity ≤0.8% |
0.05% 0.10% |
Purity By HPLC R-isomer |
≤0.15% |
0.10 |
Residue on ignition |
≤0.1% |
0.05% |
Residual solvents |
Isopropyl alcohol ≤5000ppm Ethyl Acetate   ≤5000ppm |
150ppm 250ppm |
Heavy metals |
≤10ppm |
Complies |
Chlorides |
≤0.05% |
Complies |
Assay |
98%~102.0% |
99.8% |
Conclusion |
Analyse according to Factory Standard , Conform |
Function:Â
1. Pharmacological efficacy: Pregabalin CAS 148553-50-8 is a novel γ -aminobutyric acid (GABA) receptor agonist, can block the voltage-dependent calcium channels to reduce neurotransmitter releaseÂ
2. The main clinical for the treatment of peripheral neuropathic pain as well as part of adjuvant treatment of focal seizures.Â
3. Treatment of epilepsy in developing the most promising drug in a drug treatment better and more convenient administration. Can also be used to treat pain and anxiety.Â
LYRICA (pregabalin) DESCRIPTION:
Pregabalin is described chemically as (S)-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C8H17NO2 and the molecular weight is 159.23. The chemical structure of pregabalin is:
Pregabalin is a white to off-white, crystalline solid with a pKa1 of 4.2 and a pKa2 of 10.6. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is 1.35.
LYRICA (pregabalin) oral solution, 20 mg/mL, is administered orally and is supplied as a clear, colorless solution contained in a 16 fluid ounce white HDPE bottle with a
Polyethylene-lined closure. The oral solution contains 20 mg/mL of pregabalin, along with methylparaben, propylparaben, monobasic sodium phosphate anhydrous, dibasic sodium phosphate anhydrous, sucralose, artificial strawberry #11545 and purified water as inactive ingredients.
Pregabalin is used to relieve neuropathic pain (pain from damaged nerves) that can occur in your arms, hands, fingers, legs, feet, or toes if you have diabetes or in the area of your rash if you have had shingles (a painful rash that occurs after infection with herpes zoster). It is also used to treat fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep). Pregabalin is used with other medications to treat certain types of seizures in people with epilepsy. Pregabalin is in a class of medications called anticonvulsants. It works by decreasing the number of pain signals that are sent out by damaged nerves in the body
Competitive Advantage:
1.Package will be shipped out within 24 hours
2.Discreet package guarantee package sent to you safely.
3.Success rate to USA/Canada/UK 100%, to Austrilia/Germany/France etc.99%, to New zealand 98%
4.Payment Terms: T/T, Western Union, MoneyGram
5.Factory supply products guarantee high quality products, enough stock for most of the products.
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Anticonvulsant Drugs Pregabalin CAS 148553-50-8
LYRICA (pregabalin) Capsules are administered orally and are supplied as imprinted hard-shell capsules containing 25, 50, 75, 100, 150, 200, 225, and 300 mg of pregabalin, along with lactose monohydrate, cornstarch, and talc as inactive ingredients. The capsule shells contain gelatin and titanium dioxide. In addition, the orange capsule shells contain red iron oxide and the white capsule shells contain sodium lauryl sulfate and colloidal silicon dioxide. Colloidal silicon dioxide is a manufacturing aid that may or may not be present in the capsule shells. The imprinting ink contains shellac, black iron oxide, propylene glycol, and potassium hydroxide.
Pregabalin details
CAS: 148553-50-8
MF: C8H17NO2
MW: 159.23
Assay: 99%
Appearance: White Crystal Powder
Specification: CP
Package: 25kg/drum
Use:Â New antiepileptic drugs. Used in the treatment of peripheral neuropathy, or partial seizures adjuvant treatment.
Description:
Pregabalin belongs to a group of medicines known as anti-epileptic medicines, although it is prescribed for the treatment of several different conditions. You may have been prescribed it for the treatment of partial seizures, which is a type of epilepsy. A seizure is a short episode of symptoms which is caused by a burst of abnormal electrical activity in the brain. With a partial seizure, the burst of electrical activity stays in one part of the brain. Therefore, you tend to have localised or 'focal' symptoms. Pregabalin is also prescribed to treat certain types of long-lasting pain caused by damage to nerves. This type of pain, called neuropathic pain, can be caused by a number of different conditions, including diabetes (where it is called diabetic neuropathy) and shingles(where it is called postherpetic neuralgia).
COA:
ITEMS |
STANDARDS |
RESULTS |
Appearance |
A white to off white powder |
White powder |
    Identification |
A. Meets the requirement |
Complies |
B. IR: similar to Reference Substance |
Complies |
|
Loss on drying |
≤0.5% |
0.21% |
Specific Rotation |
+10.0°~+13.0° |
+10.8° |
Related Substances |
Any single impurity ≤0.1% Total impurity ≤0.8% |
0.05% 0.10% |
Purity By HPLC R-isomer |
≤0.15% |
0.10 |
Residue on ignition |
≤0.1% |
0.05% |
Residual solvents |
Isopropyl alcohol ≤5000ppm Ethyl Acetate   ≤5000ppm |
150ppm 250ppm |
Heavy metals |
≤10ppm |
Complies |
Chlorides |
≤0.05% |
Complies |
Assay |
98%~102.0% |
99.8% |
Conclusion |
Analyse according to Factory Standard , Conform |
Function:Â
1. Pharmacological efficacy: Pregabalin CAS 148553-50-8 is a novel γ -aminobutyric acid (GABA) receptor agonist, can block the voltage-dependent calcium channels to reduce neurotransmitter releaseÂ
2. The main clinical for the treatment of peripheral neuropathic pain as well as part of adjuvant treatment of focal seizures.Â
3. Treatment of epilepsy in developing the most promising drug in a drug treatment better and more convenient administration. Can also be used to treat pain and anxiety.Â
LYRICA (pregabalin) DESCRIPTION:
Pregabalin is described chemically as (S)-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C8H17NO2 and the molecular weight is 159.23. The chemical structure of pregabalin is:
Pregabalin is a white to off-white, crystalline solid with a pKa1 of 4.2 and a pKa2 of 10.6. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is 1.35.
LYRICA (pregabalin) oral solution, 20 mg/mL, is administered orally and is supplied as a clear, colorless solution contained in a 16 fluid ounce white HDPE bottle with a
Polyethylene-lined closure. The oral solution contains 20 mg/mL of pregabalin, along with methylparaben, propylparaben, monobasic sodium phosphate anhydrous, dibasic sodium phosphate anhydrous, sucralose, artificial strawberry #11545 and purified water as inactive ingredients.
Pregabalin is used to relieve neuropathic pain (pain from damaged nerves) that can occur in your arms, hands, fingers, legs, feet, or toes if you have diabetes or in the area of your rash if you have had shingles (a painful rash that occurs after infection with herpes zoster). It is also used to treat fibromyalgia (a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep). Pregabalin is used with other medications to treat certain types of seizures in people with epilepsy. Pregabalin is in a class of medications called anticonvulsants. It works by decreasing the number of pain signals that are sent out by damaged nerves in the body
Competitive Advantage:
1.Package will be shipped out within 24 hours
2.Discreet package guarantee package sent to you safely.
3.Success rate to USA/Canada/UK 100%, to Austrilia/Germany/France etc.99%, to New zealand 98%
4.Payment Terms: T/T, Western Union, MoneyGram
5.Factory supply products guarantee high quality products, enough stock for most of the products.
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It can be used for surgical operations, patient treatment; epidemic prevention and inspection in public places; disinfection in virus-contaminated areas; and can also be widely used in military, medical, chemical, environmental protection, transportation, epidemic prevention and other field
By setting a protective collar, the neck of the operator can be kept warm and protected. The provision of a hand guard is helpful for the surgical staff to temporarily place their hands in the hand guard while waiting during the operation, which plays a protective role and is more in line with the principles of aseptic operation and occupational protection.
By setting the shrinking cuffs, it is beneficial to make the cuffs fit the wrists, prevent the cuffs from loosening, and prevent the gloves from slipping off during the operation and the operator's hands are exposed to the gloves.
The design of the new humanized protective surgical gown has been improved in the key areas of the gown. The forearm and chest area are double-thickened, and there are handguards in front of the chest and abdomen. By arranging reinforcing sheets (double-layer structure) in key areas, it is beneficial to improve the water-permeability of surgical gowns and improve safety.
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