Hormo Oral Steroid Bodybuilding 17-Alpha-Methyl Test with Top Quality

More informations maybe you want to know:
1 .What is 17-alpha-methyl test
2 .Effects about 17-alpha-methyl test
3 .Whether there have some matters need attention beofore using
4 .If there have adverse reactions during use it
5 .Our product advantage compare with others
Then you can know from the following part





*********COA 




  *********what is 17-alpha-methyl test
  17alpha-methyl test is a synthetic androgen with affinity for the  
  androgen receptor.
  

 
  
   
 *********effects about 17-alpha-methyl test
   17alpha-methyl test is used widely as a component of hormo replacement therapy. Previous reports have indicated that contrary to , 17alpha-methyl test is not aromatized. However, 17alpha-methyl test still could affect local estrogen formation by regulating aromatase expression or by inhibiting aromatase action. Both possibilities have important clinical implications. To evaluate the effect of 17alpha-methyl test on the expression and activity of aromatase, we tested the choriocarcinoma Jar cell line, a cell line that express high levels of P450 aromatase, and the macrophage-like THP-1 cells, which express aromatase only after undergoing differentiation. We found that in both cell lines, 17alpha-methyl test inhibits aromatase activity in a dose-related manner. The curve of inhibition parallels that of letrole and gives complete inhibition at 10(-4) M 17alpha-methyl test, determined by the tritium release assay. 17alpha-methyl test does not have detectable effects on aromatase RNA and protein expression by Jar cells. Undifferentiated THP-1 cells had no aromatase activity and showed no effect of 17alpha-methyl test, but differentiated THP-1 (macrophage-like) cells had a similar inhibition of aromatase activity by 17alpha-methyl test to that seen in Jar cells. The Lineweaver-Burke plot shows 17alpha-methyl test to be a competitive aromatase inhibitor. Our results show for the first time that 17alpha-methyl test acts as an aromatase inhibitor. These findings are relevant for understanding the effects of 17alpha-methyl test as a component of hormo replacement therapy. 17alpha-methyl test may, as a functional androgen and orally active steroidal inhibitor of endogenous estrogen production, also offer special possibilities for the prevention/treatment of hormo-sensitive cancers.
 




   *********Whether there have matters need attention before using
   For us,your health is the first,Some medical conditions may interact with . Tell your doctor or pharmacist if you have any medical conditions, for example:
   *if you are pregnant, planning to become pregnant, or are breast-feeding
   *if you are taking any prescription or nonprescription medicine,herbal preparation, or dietary supplement
   *if you have allergies to medicines, foods, or other substances 
   *if you have heart disease, heart failure, coronary artery disease, angina (chest pain), high cholesterol levels, swelling (edema), lung disease, or sleep apnea (long pauses in breathing while you sleep)
   *if you have diabetes, an enlarged prostate, kidney or liver disease, high blood calcium levels, or obesity
     *if you have a history of blood clots




 
 *********If there have adverse reactions during use it
   1.immediately stop using it 
   2.Going to the hospital as soon as possible,then ask doctor about reason and suggestions
   3.You can also tell me, I will do my best to help you, you are not only my customer,but also my friend 
 


*********Our Competitive Advantage 
 


Do not hesitate ,because we will be you best choose!!!
High quality with competitive price: 
1)Standard: Enterprise Standard
2)We are manufacturer and can provide high quality products with factory price. 
3)Our products only be shipped out before tested in university and lab here
Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice. 
We have clients throughout the world. 
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility. 
 
Welcome to inquiry for more details ,sara is ready to serve you !!!
 
 


More informations maybe you want to know:
1 .What is 17-alpha-methyl test
2 .Effects about 17-alpha-methyl test
3 .Whether there have some matters need attention beofore using
4 .If there have adverse reactions during use it
5 .Our product advantage compare with others
Then you can know from the following part





*********COA 




  *********what is 17-alpha-methyl test
  17alpha-methyl test is a synthetic androgen with affinity for the  
  androgen receptor.
  

 
  
   
 *********effects about 17-alpha-methyl test
   17alpha-methyl test is used widely as a component of hormo replacement therapy. Previous reports have indicated that contrary to , 17alpha-methyl test is not aromatized. However, 17alpha-methyl test still could affect local estrogen formation by regulating aromatase expression or by inhibiting aromatase action. Both possibilities have important clinical implications. To evaluate the effect of 17alpha-methyl test on the expression and activity of aromatase, we tested the choriocarcinoma Jar cell line, a cell line that express high levels of P450 aromatase, and the macrophage-like THP-1 cells, which express aromatase only after undergoing differentiation. We found that in both cell lines, 17alpha-methyl test inhibits aromatase activity in a dose-related manner. The curve of inhibition parallels that of letrole and gives complete inhibition at 10(-4) M 17alpha-methyl test, determined by the tritium release assay. 17alpha-methyl test does not have detectable effects on aromatase RNA and protein expression by Jar cells. Undifferentiated THP-1 cells had no aromatase activity and showed no effect of 17alpha-methyl test, but differentiated THP-1 (macrophage-like) cells had a similar inhibition of aromatase activity by 17alpha-methyl test to that seen in Jar cells. The Lineweaver-Burke plot shows 17alpha-methyl test to be a competitive aromatase inhibitor. Our results show for the first time that 17alpha-methyl test acts as an aromatase inhibitor. These findings are relevant for understanding the effects of 17alpha-methyl test as a component of hormo replacement therapy. 17alpha-methyl test may, as a functional androgen and orally active steroidal inhibitor of endogenous estrogen production, also offer special possibilities for the prevention/treatment of hormo-sensitive cancers.
 




   *********Whether there have matters need attention before using
   For us,your health is the first,Some medical conditions may interact with . Tell your doctor or pharmacist if you have any medical conditions, for example:
   *if you are pregnant, planning to become pregnant, or are breast-feeding
   *if you are taking any prescription or nonprescription medicine,herbal preparation, or dietary supplement
   *if you have allergies to medicines, foods, or other substances 
   *if you have heart disease, heart failure, coronary artery disease, angina (chest pain), high cholesterol levels, swelling (edema), lung disease, or sleep apnea (long pauses in breathing while you sleep)
   *if you have diabetes, an enlarged prostate, kidney or liver disease, high blood calcium levels, or obesity
     *if you have a history of blood clots




 
 *********If there have adverse reactions during use it
   1.immediately stop using it 
   2.Going to the hospital as soon as possible,then ask doctor about reason and suggestions
   3.You can also tell me, I will do my best to help you, you are not only my customer,but also my friend 
 


*********Our Competitive Advantage 
 


Do not hesitate ,because we will be you best choose!!!
High quality with competitive price: 
1)Standard: Enterprise Standard
2)We are manufacturer and can provide high quality products with factory price. 
3)Our products only be shipped out before tested in university and lab here
Fast and safe delivery
1)Parcel can be sent out in 24 hours after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice. 
We have clients throughout the world. 
1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire. 
2)Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility. 
 
Welcome to inquiry for more details ,sara is ready to serve you !!!
 
 

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